| Texto completo | |
| Autor(es): Mostrar menos - |
Victorino, Angelica Begatti
[1]
;
Serra, Fernando Tadeu
[2]
;
Pinero, Pamella Pimentel
[2]
;
De Almeida, Alexandre Aparecido
[1, 3]
;
Lopim, Glauber Menezes
[1]
;
Matias Junior, Ivair
[4]
;
Machado, Helio Rubens
[4]
;
Lent, Roberto
[5]
;
Cabral, Francisco Romero
[6]
;
Gomez-Pinilla, Fernando
[7]
;
Arida, Ricardo Mario
[1]
;
Da Silva, Sergio Gomes
[2, 6]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo UNIFESP, Sao Paulo, SP - Brazil
[2] Univ Mogi das Cruzes, Mogi Das Cruzes, SP - Brazil
[3] Inst Fed Goiano, Campus Ceres, Ceres, GO - Brazil
[4] Univ Sao Paulo, FMRP, Sao Paulo, SP - Brazil
[5] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Rio De Janeiro, RJ - Brazil
[6] HIAE, Sao Paulo, SP - Brazil
[7] Univ Calif Los Angeles, Los Angeles, CA - USA
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience; v. 361, p. 108-115, OCT 11 2017. |
| Citações Web of Science: | 6 |
| Resumo | |
Better cognitive performance and greater cortical and hippocampal volume have been observed in individuals who undertook aerobic exercise during childhood and adolescence. One possible explanation for these beneficial effects is that juvenile physical exercise enables better neural development and hence more cells and neuronal circuitries. It is probable that such effects occur through intracellular signaling proteins associated with cell growth, proliferation and survival. Based on this information, we evaluated the number of neuronal and non-neuronal cells using isotropic fractionation and the expression and activation of intracellular proteins (ERK, CREB, Akt, mTOR and p70S6K) in the cerebral cortex and hippocampal formation of the rats submitted to a physical exercise program on a treadmill during adolescence. Results showed that physical exercise increases the number of neuronal and non neuronal cortical cells and hippocampal neuronal cells in adolescent rats. Moreover, mTOR overexpression was found in the cortical region of exercised adolescent rats. These findings indicate a significant cellular proliferative effect of aerobic exercise on the cerebral cortex in postnatal development. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 14/00035-1 - Reserva neural induzida pela prática de atividade física na adolescência: um estudo do fator neurotrófico derivado do encéfalo (BDNF), de seus receptores (TrkB e P75ntr) e vias de sinalização intracelular |
| Beneficiário: | Sérgio Gomes da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |