Biotechnological applications of bacteriophages: State of the art

Autor(es)

Harada, Liliam K. ^[1] ; Silva, Erica C. ^[1] ; Campos, Welida F. ^[1] ; Del Fiol, Fernando S. ^[1] ; Vila, Marta ^[1] ; Dabrowska, Krystyna ^[2] ; Krylov, Victor N. ^[3] ; Balcao, Victor M. ^{[4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, Ibs 2 Intelligent Biosensing & Biomol Stabilizat, PhageLab Lab Biofilms & Bacteriophages, Sorocaba, SP - Brazil

^[2] Polish Acad Sci, Inst Immunol & Expt Therapy, Bacteriophage Lab, Wroclaw - Poland

^[3] Russian Acad Med Sci, Mechnikov Res Inst Vaccines & Sera, Lab Genet Bacteriophages, State Inst Genet & Select Ind Microorganisms, 1st Dorozhnii Proezd 1, Moscow 113545 - Russia

^[4] Univ Minho, CEB Ctr Biol Engn, Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: MICROBIOLOGICAL RESEARCH; v. 212, p. 38-58, 2018.
• Citações Web of Science: 13

Resumo

Bacteriophage particles are the most abundant biological entities on our planet, infecting specific bacterial hosts in every known environment and being major drivers of bacterial adaptive evolution. The study of bacteriophage particles potentially sheds light on the development of new biotechnology products. Bacteriophage therapy, although not new, makes use of strictly lytic phage particles as an alternative in the antimicrobial treatment of resistant bacterial infections and is being rediscovered as a safe method due to the fact that these biological entities devoid of any metabolic machinery do not have affinity to eukaryotic cells. Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. This review paper discusses the biological nature of bacteriophage particles, their mode(s) of action and potential exploitation in modern biotechnology. Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene delivery, food biopreservation and safety, biocontrol of plant pathogens, phage display, bacterial biosensing devices, vaccines and vaccine carriers, biofilm and bacterial growth control, surface disinfection, corrosion control, together with structural and functional stabilization issues. (AU)

• Processo FAPESP: 16/08884-3 - PneumoPhageColor - desenvolvimento de um kit de biodetecção colorimétrica de Pseudomonas aeruginosa com base em partículas fágicas
• Beneficiário: Vitor Manuel Cardoso Figueiredo Balcão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16641-3 - Estabilização estrutural e funcional de sericina em hidrogel biopolissacarídico: bio-origami para a regeneração de pele
• Beneficiário: Liliam Katsue Harada Rocha
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/12234-4 - TransAppIL - Permeação cutânea de entidades proteicas estabilizadas estruturalmente e funcionalmente, carreadas por líquidos iônicos.
• Beneficiário: Marta Maria Duarte Carvalho Vila
• Modalidade de apoio: Auxílio à Pesquisa - Regular