Development and characterization of the InVesalius Navigator software for navigated transcranial magnetic stimulation

Autor(es)

Souza, Victor Hugo ^{[1, 2]} ; Matsuda, Renan H. ^[1] ; Peres, Andre S. C. ^{[1, 3]} ; Amorim, Paulo Henrique J. ^[4] ; Moraes, Thiago F. ^[4] ; Silva, Jorge Vicente L. ^[4] ; Baffa, Oswaldo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Fis, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

^[2] Aalto Univ, Dept Neurosci & Biomed Engn, Sch Sci, POB 12200, FI-00076 Aalto - Finland

^[3] Inst Santos Dumont, Inst Int Neurociencia Natal Edmond & Lily Safra, Rodovia RN 160 Km 03, 3003, BR-59280000 Macaiba, RN - Brazil

^[4] Ctr Tecnol Informacao Renato Archer, Nucleo Tecnol Tridimensionais, Rodovia Dom Pedro 1 Km 143, BR-13069901 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEUROSCIENCE METHODS; v. 309, p. 109-120, NOV 1 2018.
• Citações Web of Science: 3

Resumo

Background: Neuronavigation provides visual guidance of an instrument during procedures of neurological interventions, and has been shown to be a valuable tool for accurately positioning transcranial magnetic stimulation (TMS) coils relative to an individual's anatomy. Despite the importance of neuronavigation, its high cost, low portability, and low availability of magnetic resonance imaging facilities limit its insertion in research and clinical environments. New method: We have developed and validated the InVesalius Navigator as the first free, open-source software for image-guided navigated TMS, compatible with multiple tracking devices. A point-based, co-registration algorithm and a guiding interface were designed for tracking any instrument (e.g. TMS coils) relative to anindividual's anatomy. Results: Localization, precision errors, and repeatability were measured for two tracking devices during navigation in a phantom and in a simulated TMS study. Errors were measured in two commercial navigated TMS systems for comparison. Localization error was about 1.5 mm, and repeatability was about 1 mm for translation and 1 for rotation angles, both within limits established in the literature. Comparison with existing methods: Existing TMS neuronavigation software programs are not compatible with multiple tracking devices, and do not provide an easy to implement platform for custom tools. Moreover, commercial alternatives are expensive with limited portability. Conclusions: InVesalius Navigator might contribute to improving spatial accuracy and the reliability of techniques for brain interventions by means of an intuitive graphical interface. Furthermore, the software can be easily integrated into existing neuroimaging tools, and customized for novel applications such as multi-locus and/or controllable-pulse TMS. (AU)

• Processo FAPESP: 09/09064-6 - Co-registro do campo vetorial de estimulação transcraniana magnética com imagens de ressonância magnética
• Beneficiário: Victor Hugo de Oliveira e Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/11937-0 - Avaliação por Eletromiografia de Alta Densidade do Recrutamento Muscular em Aplicações de Estimulação Magnética Transcraniana com Posicionamento Neuronavegado
• Beneficiário: Victor Hugo de Oliveira e Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/03293-2 - Implementacao de um sistema de localizacao espacial de regioes cerebrais em tempo real para aplicacao de tms por co-registro com mri.
• Beneficiário: André Salles Cunha Peres
• Modalidade de apoio: Bolsas no Brasil - Mestrado