Mesoporous bioactive glasses: Promising platforms for antibacterial strategies

Autor(es)

Kargozar, Saeid ^[1] ; Montazerian, Maziar ^[2] ; Harnzehlou, Sepideh ^{[3, 4]} ; Kim, Hae-Won ^{[5, 6, 7, 8]} ; Baino, Francesco ^[9]

Afiliação do(s) autor(es)

^[1] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, POB 917794-8564, Mashhad - Iran

^[2] Univ Fed Sao Carlos, Ctr Res Technol & Educ Vitreous Mat CeRTEV, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran 141556447 - Iran

^[4] USERN, Med Genet Network MeGeNe, Tehran - Iran

^[5] Dankook Univ, Sch Dent, Dept Biomat Sci, Cheonan 31116 - South Korea

^[6] Dankook Univ, Inst Tissue Regenerat Engn ITREN, Cheonan 31116 - South Korea

^[7] Dankook Univ, Dept Nanobiomed Sci, Cheonan 31116 - South Korea

^[8] Dankook Univ, PLUS NBM Global Res Ctr Regenerat Med Res Ctr BK2, Cheonan 31116 - South Korea

^[9] Politecn Torino, Appl Sci & Technol Dept, Inst Mat Phys & Engn, Corso Duca Abruzzi 24, I-10129 Turin - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: Acta Biomaterialia; v. 81, p. 1-19, NOV 2018.
• Citações Web of Science: 21

Resumo

The control of bacterial infections is of particular importance in the field of tissue engineering. Recently, much attention has been addressed toward the use of mesoporous bioactive glasses (MBGs) for antibacterial strategies, primarily because of their capability of acting as carriers for the local release of antimicrobial agents. The incorporation of antibacterial metallic ions including silver (Ag+), zinc (Zn2+), copper (Cu+ and Cu2+), cerium (Ce3+ and Ce4+), and gallium (Ga3+) cations into the MBG structure and their controlled release is proposed as one of the most attractive strategies for inhibiting bacterial growth and reproduction. Moreover, the possibility of loading and delivering various antibacterial biomolecules (e.g., antibiotics) through the porous structure of MBGs makes them as ideal candidates for antibacterial applications. In this review, we aim to present a comprehensive evaluation of MBG potential regarding antibacterial activities. For this purpose, different types of antibacterial ion-doped and drug-loaded MBGs are introduced and discussed in the light of existing knowledge, along with the significant challenges ahead. Statement of significance Prevention and treatment of infections is one of the today's greatest challenges in medical sciences, also considering the well-known issues related to increased bacterial resistance to antibiotics. The advent of mesoporous glasses led to the birth of a new class of multifunctional biomaterials acting as bioactive platforms for the local release of organic or inorganic agents eliciting an antimicrobial effect. This reviews summarizes the state of the art of MBGs in this field, highlighting the latest evolutions and the specific role played by metallic antimicrobial ions that can be incorporated in the glass composition and then properly released. Perspective for tissue engineering applications are also discussed to provide an up-to-date contribution that is useful to both experienced scientists and early-stage researchers. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/13314-9 - Desenvolvimento e caracterização de vitrocerâmicos bioativos e tenazes
• Beneficiário: Maziar Montazerian
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado