Augmented Anabolic Responses after 8-wk Cycling with Blood Flow Restriction

Autor(es):Mostrar menos -

Conceicao, Miguel S. ^{[1, 2]} ; Junior, Edson M. M. ^[2] ; Telles, Guilherme D. ^[2] ; Libardi, Cleiton A. ^[3] ; Castro, Alex ^[2] ; Andrade, Andre L. L. ^[2] ; Brum, Patricia C. ^[1] ; Urias, Ursula ^[1] ; Kurauti, Mirian Ayumi ^[4] ; Costa Junior, Jose Maria ^[4] ; Boscher, Antonio Carlos ^[4] ; Cavaglieri, Claudia R. ^[2] ; Camera, Donny M. ^[5] ; Chacon-Mikahil, Mara P. T. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Phys Educ, Av Erico Verissimo 701, BR-13083851 Campinas, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Phys Educ, Lab Neuromuscular Adaptat Resistance Training, MuscuLab, Sao Carlos, SP - Brazil

^[4] Univ Estadual Campinas, Inst Biol, OCRC, Campinas, SP - Brazil

^[5] Australian Catholic Univ, Ctr Exercise & Nutr, Mary MacKillop Inst Hlth Res, Melbourne, Vic - Australia

• Tipo de documento: Artigo Científico
• Fonte: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 51, n. 1, p. 84-93, JAN 2019.
• Citações Web of Science: 4

Resumo

Introduction Low-intensity endurance training (ET) performed with blood flow restriction (BFR) can improve muscle strength, cross-sectional area (CSA) and cardiorespiratory capacity. Whether muscle strength and CSA as well as cardiorespiratory capacity (i.e., VO2max) and underlying molecular processes regulating such respective muscle adaptations are comparable to resistance and ET is unknown. Purpose To determine the respective chronic (i.e., 8 wk) functional, morphological, and molecular responses of ET-BFR training compared with conventional, unrestricted resistance training (RT) and ET. Methods Thirty healthy young men were randomly assigned to one of three experimental groups: ET-BFR (n = 10, 4 dwk(-1), 30-min cycling at 40% of VO2max), RT (n = 10, 4 dwk(-1), 4 sets of 10 repetitions leg press at 70% of one repetition maximum with 60 s rest) or ET (n = 10, 4 dwk(-1), 30-min cycling at 70% of VO2max) for 8 wk. Measures of quadriceps CSA, leg press one repetition maximum, and VO2max as well as muscle biopsies were obtained before and after intervention. Results Both RT and ET-BFR increased muscle strength and hypertrophy responses. ET-BFR also increased VO2max, total cytochrome c oxidase subunit 4 isoform 1 abundance and vascular endothelial growth factor mRNA abundance despite the lower work load compared to ET. Conclusions Eight weeks of ET-BFR can increase muscle strength and induce similar muscle hypertrophy responses to RT while VO2max responses also increased postintervention even with a significantly lower work load compared with ET. Our findings provide new insight to some of the molecular mechanisms mediating adaptation responses with ET-BFR and the potential for this training protocol to improve muscle and cardiorespiratory capacity. (AU)

• Processo FAPESP: 14/00985-0 - Efeitos de 12 semanas de treinamento concorrente na resposta de sinalização molecular em idosos
• Beneficiário: Miguel Soares Conceição
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/19756-3 - Efeito do treinamento concorrente na modulação das células satélites musculares e na taxa de síntese protéica miofibrilar
• Beneficiário: Miguel Soares Conceição
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado