Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity

Autor(es)

Souza-Moreira, Tatiana M. ^{[1, 2]} ; Severi, Juliana A. ^[1] ; Rodrigues, Edvanio Ramos ^[1] ; de Paula, Mayara Ivani ^[1] ; Freitas, Jolindo A. ^[1] ; Vilegas, Wagner ^[2] ; Pietro, Rosemeire C. L. R. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Araraquara - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Organ Chem, Araraquara - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. 33, n. 17, p. 2579-2582, SEP 2 2019.
• Citações Web of Science: 5

Resumo

Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 mu g/mL), C. parapsilosis (78 mu g/mL), C. krusei (19 mu g/mL), Trichophyton rubrum (78 mu g/mL) and Microsporum canis (156 mu g/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum. (AU)

• Processo FAPESP: 08/00039-6 - Estudo da composição química e atividade antifúngica de Plinia cauliflora (Mart.) Kausel (Myrtaceae)
• Beneficiário: Rosemeire Cristina Linhari Rodrigues Pietro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/50645-7 - Estudo da composicao quimica e atividade antifungica de melaleuca alternifolia cheel (myrtaceae) e de plinia cauliflora (mart.) kausel (myrtaceae) para desenvolvimento de preparacoes farmaceuticas.
• Beneficiário: Tatiana Maria de Souza Moreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado