Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves

Autor(es)

Dias Silva, Marcelo J. ^[1] ; Simonet, Ana M. ^[2] ; Silva, Naiara C. ^[3] ; Dias, Amanda L. T. ^[3] ; Vilegas, Wagner ^[1] ; Macias, Francisco A. ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Biosci Inst, Coastal Campus Sao Vicente, BR-11330900 Sao Vicente, SP - Brazil

^[2] Univ Cadiz, Fac Ciencias, Inst Biomol INBIO, Grp Alelopatia, Dept Quim Organ, C Republ Saharaui 7, Puerto Real 11510, Cadiz - Spain

^[3] UNIFAL Univ Fed Alfenas, Fac Pharmaceut Sci, Rua Gabriel Monteir da Silva 714, BR-37130000 Alfenas, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 82, n. 6, p. 1496-1502, JUN 2019.
• Citações Web of Science: 1

Resumo

A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activity permitted the identification of 28 compounds, including the new 6-(beta-boivinopyranosyl)apigenin (1), 8-(beta-oliopyranosyl)-apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2-carboxyethenyl)apigenin (4), and 7,5 `'-anhydro-6-(alpha-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC50 44 nM), which exhibits resistance to azoles. The association of the major components 3-beta-D-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C. krusei, especially the IC values of compound 10, which were reduced by more than 100-fold. (AU)

• Processo FAPESP: 15/21479-8 - Padronização dos extratos vegetais de Mimosa spp. no desenvolvimento de fitomedicamentos
• Beneficiário: Marcelo José Dias Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/18760-9 - Extratos vegetais padronizados para o tratamento de doenças crônicas: Mimosa spp.
• Beneficiário: Marcelo José Dias Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/52237-9 - Fitoterápicos padronizados como alvo para o tratamento de doenças crônicas
• Beneficiário: Wagner Vilegas
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático