| Texto completo | |
| Autor(es): |
Uehara, Thiers M.
[1]
;
Paino, Ieda M. M.
[1]
;
Santos, Fabricio A.
[1]
;
Scagion, Vanessa P.
[2, 3]
;
Correa, Daniel S.
[2, 3]
;
Zucolotto, Valtencir
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Phys Inst Sao Carlos, Nanomed & Nanotoxicol Grp, BR-369 Sao Carlos, SP - Brazil
[2] Embrapa Instrumentacao, LNNA, BR-13560970 Sao Carlos - Brazil
[3] Fed Univ Sao Carlos UFSCar, PPGQ, Dept Chem, Ctr Exact Sci & Technol, Sao Carlos - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | POLYMERS FOR ADVANCED TECHNOLOGIES; v. 31, n. 6 MAR 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Graphene oxide (GO)-based materials have been explored in biomedical applications as active engineered materials for diagnosis and therapy. Although a large number of studies have been carried out in the last years, aspects involving the orientation and elongation of cells on GO immobilized on polymeric nanofibers are still scarce. We investigated the interactions between skeletal muscle cells and GO immobilized on random and aligned electrospun nanofibers of poly(caprolactone) (PCL), a biocompatible and biodegradable polymer. Oxygen plasma was employed to modify the nanofiber polymer surface to enhance the interactions between the PCL fibers and GO. Scanning electron microscopy and confocal microscopy revealed the morphology and orientation of skeletal muscle cells (C2C12 cells) on random and aligned GO/PCL nanofibers. The approach employed here is useful to investigate the interaction of skeletal muscle cells with biocompatible polymer nanofibers modified with GO intended for cell scaffolds and tissue engineering. (AU) | |
| Processo FAPESP: | 13/21292-0 - Estudo da interação de óxido de grafeno com modelos de membranas celulares e com células-tronco |
| Beneficiário: | Thiers Massami Uehara |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/12174-4 - Desenvolvimento de nanofibras poliméricas híbridas para aplicação na agricultura |
| Beneficiário: | Daniel Souza Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |