On the usefulness of parental lines GWAS for predicting low heritability traits in tropical maize hybrids

Autor(es)

Galli, Giovanni ^[1] ; Alves, Filipe Couto ^[2] ; Morosini, Julia Silva ^[1] ; Fritsche-Neto, Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Genet, Piracicaba, SP - Brazil

^[2] Michigan State Univ, Inst Quantitat Hlth Sci & Engn, E Lansing, MI 48824 - USA

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 15, n. 2 FEB 7 2020.
• Citações Web of Science: 0

Resumo

Genome-wide association studies (GWAS) is one of the most popular methods of studying the genetic control of traits. This methodology has been intensely performed on inbred genotypes to identify causal variants. Nonetheless, the lack of covariance between the phenotype of inbred lines and their offspring in cross-pollinated species (such as maize) raises questions on the applicability of these findings in a hybrid breeding context. To address this topic, we incorporated previously reported parental lines GWAS information into the prediction of a low heritability trait in hybrids. This was done by marker-assisted selection based on significant markers identified in the lines and by genomic prediction having these markers as fixed effects. Additive-dominance GWAS of hybrids, a non-conventional procedure, was also performed for comparison purposes. Our results suggest that incorporating information from parental inbred lines GWAS led to decreases in the predictive ability of hybrids. Correspondingly, inbred lines and hybrids-based GWAS yielded different results. These findings do not invalidate GWAS on inbred lines for selection purposes, but mean that it may not be directly useful for hybrid breeding. (AU)

• Processo FAPESP: 13/24135-2 - Associação genômica para eficiência no uso de nitrogênio e seus componentes em linhagens de milho tropical
• Beneficiário: Roberto Fritsche Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/24327-0 - TCGA: um painel de germoplasmas de milho tropical para estudos de predição genômica e fenotipagem de alto rendimento
• Beneficiário: Roberto Fritsche Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/25549-6 - Predição genômica aplicada à seleção recorrente recíproca em milho tropical para eficiência no uso de nitrogênio
• Beneficiário: Júlia Silva Morosini
• Modalidade de apoio: Bolsas no Brasil - Doutorado