Beneficial Effects of Isoflavones in the Kidney of Obese Rats Are Mediated by PPAR-Gamma Expression

Autor(es):Mostrar menos -

Pessoa, Edson de Andrade ^[1] ; Convento, Marcia Bastos ^[1] ; Castino, Bianca ^[2] ; Leme, Ala Moana ^[1] ; de Oliveira, Andreia Silva ^[1] ; Aragao, Alef ^[2] ; Fernandes, Sheila Marques ^[3] ; Carbonel, Adriana ^[4] ; Dezoti, Cassiane ^[3] ; Vattimo, Maria de Fatima ^[5] ; Schor, Nestor ^[1] ; Borges, Fernanda Teixeira ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Med, Nephrol Div, BR-04023900 Sao Paulo, SP - Brazil

^[2] Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Nursing, Expt Lab Anim Model, BR-05403000 Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Morphol & Genet, Histol & Struct Biol Div, BR-04039032 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, BR-05403000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 12, n. 6 JUN 2020.
• Citações Web of Science: 0

Resumo

Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce renal damage in order to evaluate whether soy isoflavones could have promising use in the treatment of renal alterations. After two months of ingestion, there was an expansion of visceral fat, which was associated with long-term metabolic disorders, such as sustained hyperglycemia, insulin resistance, polyuria, dyslipidemia, and hypertension. Additionally, we found a decrease in renal blood flow and an increase in renal vascular resistance. Biochemical markers of chronic kidney disease were detected; there was an infiltration of inflammatory cells with an elevated expression of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1 beta), the activation of the renin-angiotensin system, and oxidative/nitrosative stress. Notably, in rats exposed to the DH diet for 120 days, the concomitant treatment with isoflavones after 60 days was able to revert metabolic parameters, renal alterations, and oxidative/nitrosative stress. The beneficial effects of isoflavones in the kidney of the obese rats were found to be mediated by expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma). (AU)

• Processo FAPESP: 10/52180-4 - Fisiopatologia e regeneração das lesões renais
• Beneficiário: Nestor Schor
• Modalidade de apoio: Auxílio à Pesquisa - Temático