Host immune responses in dermatophytes infection

Autor(es)

Celestrino, Giovanna Azevedo ^{[1, 2]} ; Veasey, John Verrinder ^[3] ; Benard, Gil ^{[1, 2]} ; Teixeira Sousa, Maria Gloria ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lab Micol Med LIM 53, Div Dermatol Clin, Fac Med, Hosp Clin, Sao Paulo - Brazil

^[3] Hosp Santa Casa Sao Paulo, Clin Dermatol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MYCOSES; v. 64, n. 5 FEB 2021.
• Citações Web of Science: 1

Resumo

Dermatophytosis is a skin infection caused by keratinophilic, filamentous fungi. These are highly prevalent, common mycoses, affecting approximately 20% of the population. These fungi invade the stratum corneum, and other keratinised tissues, like nails and hair, where they grow by secreting enzymes and degrading keratin to obtain nutrients. Clinical presentation is variable and may depend on many factors, such as the infection site, the host's immunity and the dermatophyte's virulence. Generally, patients with acute superficial dermatophytosis mount cell-mediated immune responses. However, those suffering from chronic or recurrent infections are unable to develop this response, for reasons yet unknown. Several reports have described severe and occasionally life-threatening invasive diseases (deep dermatophytosis) associated with genetic mutations in the innate immunity-associated molecule CARD9, displaying the need to better understand its immune response. These dermatoses have substantial clinical consequences, producing chronic and difficult to treat skin lesions. They also lead to a decline in the patient's quality of life and impact their self-esteem. This review summarises findings on the immune response against dermatophytes. (AU)

• Processo FAPESP: 16/16369-1 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/26208-8 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 18/16146-8 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Giovanna Azevedo Celestrino
• Modalidade de apoio: Bolsas no Brasil - Mestrado