How the Strain Origin of Zika Virus NS1 Protein Impacts Its Dynamics and Implications to Their Differential Virulence

Autor(es)

Poveda-Cuevas, Sergio A. ^{[1, 2, 3, 4]} ; Barroso da Silva, Fernando Luis ^{[1, 2, 5, 3, 4]} ; Etchebest, Catherine ^{[6, 1, 4, 7, 8]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Programa Interunidades Bioinformat, BR-05508090 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias BioMol, BR-14040903 Ribeirao Preto, SP - Brazil

^[4] Univ Paris, Int Lab Struct Bioinformat, BR-14040903 Ribeirao Preto, SP - Brazil

^[5] North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 - USA

^[6] Inst Natl Transfus Sanguine, F-75015 Paris - France

^[7] INSERM, Dynam Struct & Interact Mol, Biol Integree Globule Rouge Equipe 2, UMR S 1134, Paris - France

^[8] Univ Paris, F-75013 Paris - France

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CHEMICAL INFORMATION AND MODELING; v. 61, n. 3, p. 1516-1530, MAR 22 2021.
• Citações Web of Science: 0

Resumo

Viruses can impact and affect human populations in a severe way. The appropriate differentiation among several species or strains of viruses is one of the biggest challenges for virology and infectiology studies. The detection of measurables-quantified discrepancies allows for more accurate clinical diagnoses and treatments for viral diseases. In the present study, we have used a computational approach to explore the dynamical properties of the nonstructural protein 1 from two strains of Zika virus. Our results show that despite a high sequence similarity, the two viral proteins from different origins can exhibit significant dissimilar structural dynamics, which complement their reported differential virulence. The present study opens up new ways in the understanding of the infectivity for these biological entities. (AU)

• Processo FAPESP: 15/16116-3 - Mecanismos moleculares de origem eletrostática responsáveis pela complexação de proteínas
• Beneficiário: Fernando Luis Barroso da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/07158-2 - Desenvolvendo e aplicando métodos de simulação computacional para melhorar a compreensão molecular para a engenharia de biomateriais funcionalizados
• Beneficiário: Fernando Luis Barroso da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular