Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

Autor(es)

Bernardo, Marcela Piassi ^[1] ; Rodrigues da Silva, Bruna Cristina ^[1] ; Capparelli Mattoso, Luiz Henrique ^[1]

Afiliação do(s) autor(es)

^[1] Brazilian Agr Res Corp, Natl Nanotechnol Lab Agribusiness, Embrapa Instrumentat, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF COMPOSITE MATERIALS; v. 55, n. 17, p. 2289-2300, JUL 2021.
• Citações Web of Science: 0

Resumo

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft. (AU)

• Processo FAPESP: 18/07860-9 - Desenvolvimento de filamentos nanocompósitos poliméricos com propriedades anti-inflamatórias para impressão 3D como substituintes ósseos
• Beneficiário: Marcela Piassi Bernardo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado