| Texto completo | |
| Autor(es): |
de Oliveira, Amanda R.
[1, 2]
;
Reimer, Adriano E.
[2]
;
Simandl, Gregory J.
[2]
;
Nagrale, Sumedh S.
[2]
;
Widge, Alik S.
[2]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Fed Univ Sao Carlos UFSCar, Dept Psychol, Sao Carlos, SP - Brazil
[2] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 - USA
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TRANSLATIONAL PSYCHIATRY; v. 11, n. 1 MAY 24 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
The orbitofrontal cortex-ventromedial striatum (OFC-VMS) circuitry is widely believed to drive compulsive behavior. Hyperactivating this pathway in inbred mice produces excessive and persistent self-grooming, which has been considered a model for human compulsivity. We aimed to replicate these findings in outbred rats, where there are few reliable compulsivity models. Male Long-Evans rats implanted with optical fibers into VMS and with opsins delivered into OFC received optical stimulation at parameters that produce OFC-VMS plasticity and compulsive grooming in mice. We then evaluated rats for compulsive self-grooming at six timepoints: before, during, immediately after, and 1h after each stimulation, 1 and 2 weeks after the ending of a 6-day stimulation protocol. To further test for effects of OFC-VMS hyperstimulation, we ran animals in three standard compulsivity assays: marble burying, nestlet shredding, and operant attentional set-shifting. OFC-VMS stimulation did not increase self-grooming or induce significant changes in nestlet shredding, marble burying, or set-shifting in rats. Follow-on evoked potential studies verified that the stimulation protocol altered OFC-VMS synaptic weighting. In sum, although we induced physiological changes in the OFC-VMS circuitry, we could not reproduce in a strongly powered study in rats a model of compulsive behavior previously reported in mice. This suggests possible limitations to translation of mouse findings to species higher on the phylogenetic chain. (AU) | |
| Processo FAPESP: | 17/22473-9 - Efeitos da estimulação optogenética córtico-estriatal persistente sobre a flexibilidade comportamental na busca por um modelo animal de Transtorno Obsessivo-Compulsivo (TOC) |
| Beneficiário: | Amanda Ribeiro de Oliveira |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |