Critical Parameters for Green Glycoluril Synthesis

Autor(es)

Soares, R. S. B. ^[1] ; Souza, L. R. R. ^[2] ; Bertolucci, M. M. ^[2] ; Oliveira, A. de ^[3] ; Demets, G. J. F. ^[2] ; Araki, K. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, DQ FFCLRP, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] OGSC Chem Ind Consulting, BR-05015001 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RUSSIAN JOURNAL OF GENERAL CHEMISTRY; v. 91, n. 4, p. 739-742, APR 2021.
• Citações Web of Science: 0

Resumo

We have studied the critical parameters of Micheletti's glycoluril synthesis starting from urea and glyoxal on a statistical and multivariate analysis basis {[}12]. The process is potentially highly useful for scaling-up glycoluril production, and needs to be optimized. We have come to a conclusion that H3PO4 could be used as well as P4O10 giving high yields at temperature around 95 degrees C, using glyoxal without prior purification. All reactions have been completed in less than 25 min with the yield as high as 80% under the optimized conditions. (AU)

• Processo FAPESP: 18/21489-1 - Nanotecnologia supramolecular: design, materiais e dispositivos
• Beneficiário: Henrique Eisi Toma
• Modalidade de apoio: Auxílio à Pesquisa - Temático