Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020

Autor(es)

de Carvalho, Ana Calheiros ^[1] ; Ogawa, Jr., Claudio Yoshio ^[1] ; De Camillis Rodrigues, Luiza ^[1] ; de Medeiros, Livia Soman ^[1] ; Veiga, Thiago Andre Moura ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Chem, Diadema - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Leukemia & Lymphoma; v. 62, n. 9, p. 2079-2093, JUL 29 2021.
• Citações Web of Science: 0

Resumo

Penicillium is a widely explored genus due to its chemical diversity and associated biological properties; in addition, it represents an important source for cytotoxic compounds with good application perspectives. Based on these aspects, in this review, Penicillium compounds that presented activity against human leukemia cell lines are being listed and discussed. For this, a careful bibliographic survey was carried out in the main electronic databases, i.e. Scopus, SciFinder, Web of Science and Pubmed. Between 1984 and 2020, thirty seven original papers were selected, when using the search terms Penicillium and leukemia. The occurrence of l-asparaginase produced by some Penicillium spp. was also highlighted since this enzyme is being employed for acute lymphoblastic leukemia and lymphosarcoma therapies. Therefore, this overview aims to demonstrate the potential of metabolites biosynthesized by Penicillium fungi which can be applied in human leukemia therapies and opportunities for designing new lead compounds. (AU)

• Processo FAPESP: 18/04095-0 - Abordagens analíticas para a descoberta de compostos citotóxicos desconhecidos a partir de plantas
• Beneficiário: Thiago André Moura Veiga
• Modalidade de apoio: Auxílio à Pesquisa - Regular