| Texto completo | |
| Autor(es): Mostrar menos - |
Firmino, Pollyana P.
;
Queiroz, Jaqueline E.
;
Dias, Lucas D.
;
Wenceslau, Patricia R. S.
;
de Souza, Larissa M.
;
Iermak, Ievgeniia
;
Vaz, Wesley F.
;
Custodio, Jean M. F.
;
Oliver, Allen G.
;
de Aquino, Gilberto L. B.
;
Napolitano, Hamilton B.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CRYSTALS; v. 12, n. 4, p. 18-pg., 2022-04-01. |
| Resumo | |
Chalcones belong to the flavonoids family and are natural compounds which show promising larvicidal property against Aedes aegypti larvae. Aiming to obtain a synthetic chalcone derivative with high larvicidal activity, herein, a bromochalcone derivative, namely (E)-3-(4-butylphenyl)-1-(4-bromophenyl)-prop-2-en-1-one (BBP), was designed, synthesized and extensively characterized by H-1- and C-13- nuclear magnetic resonance (NMR), infrared (IR), Raman spectroscopy, mass spectrometry (MS), ultraviolet-visible spectroscopy (UV-Vis), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and X-ray diffraction. Further, the quantum mechanics calculations implemented at the B3LYP/6-311+G(d)* level of the theory indicate that the supramolecular arrangement was stabilized by C-HMIDLINE HORIZONTAL ELLIPSISO and edge-to-face C-HMIDLINE HORIZONTAL ELLIPSIS pi interactions. The EGAP calculated (3.97 eV) indicates a good reactivity value compared with other similar chalcone derivatives. Furthermore, the synthesized bromochalcone derivative shows promising larvicidal activity (mortality up to 80% at 57.6 mg center dot L-1) against Ae. aegypti larvae. (AU) | |
| Processo FAPESP: | 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica |
| Beneficiário: | Vanderlei Salvador Bagnato |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 14/50857-8 - Inct 2014 - de optica basica e aplicada as ciencias da vida. |
| Beneficiário: | Vanderlei Salvador Bagnato |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/13569-8 - Estudo dos Mecanismos de Ação em Terapia Fotodinâmica: Do Fotossensibilizador à Aplicação Prática |
| Beneficiário: | Lucas Danilo Dias |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |