Study of the Photo Oxidative Action of Brosimum gaudichaudii Extract

Autor(es)

Antunes, V. M. de S. ; Sena, C. L. de L. ; Uchoa, A. F. ; Bastos-Filho, TF ; Caldeira, EMD ; Frizera-Neto, A

• Tipo de documento: Artigo Científico
• Fonte: XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020; v. N/A, p. 4-pg., 2022-01-01.

Resumo

Brosimum gaudichaudii (BG) is a medicinal plant native from Brazil and popularly known as mamica-de-cadela, mamacadela, among others. It presents as main metabolites coumarins and furanocoumarins, recognized photoactive agents. There are several studies that indicate the photodynamic action of Brosimum gaudichaudii extracts. The purpose of this study was to perform photophysical studies of the aerial parts of the plant extract for application in photodynamic therapy. The results of this study were determined by the absorption spectrum in the ultraviolet (UV) and visible regions, as well as the emission spectrum when excited at different wavelengths. In the region of 345 nm, the stem extracts stand out, since this region is where bergaptenes and other furanocoumarins absorb light. In the region 667 nm all the extracts were found, mainly those of the leaves, and in this region chlorophyll absorbs light, which shows the contribution of chlorophyll in the process. The photodynamic potential action of the extracts by solar irradiation was attributed to a synergism by action on UV and chlorophyll and its derivatives in the photodynamic therapy. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs