| Texto completo | |
| Autor(es): |
de Oliveira, Matheus F.
;
da Silva, Laura C. E.
;
Catori, Daniele M.
;
Lorevice, Marcos, V
;
Galvao, Karen E. A.
;
Millas, Ana L. G.
;
de Oliveira, Marcelo G.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Macromolecular Bioscience; v. N/A, p. 14-pg., 2022-12-25. |
| Resumo | |
The design of bioresorbable vascular stents (BVS) capable of releasing nitric oxide (NO) at the implant site may enable BVS to mimic the antiplatelet, antiproliferative, and pro-endothelial actions of NO, overcoming complications of BVS such as late thrombosis and restenosis. In this study, the fabrication of BVS composed of methacrylated poly(dodecanediol citrate-co-dodecanediol S-nitroso-mercaptosuccinate) (mP(DC-co-DMSNO)), a novel elastomeric, bioabsorbable, and photocurable copolyester, containing covalently bound S-nitrosothiol groups in the carbon backbone of the polymer, is reported. The mP(DC-co-DMSNO) stents are manufactured via photoinduced 3D printing and allow deployment via a self-expansion process from a balloon catheter. After deployment, hydration of the stents triggers the release of NO, which is maintained during the slow hydrolysis of the polymer. Real-time NO release measurements show that by varying the copolyester composition and the strut geometry of the mP(DC-co-DMSNO) stents, it is possible to modulate their NO release rate in the range of 30-52 pmol min(-1) cm(-2). Preliminary biological assays in cell culture show that endothelial cells adhere to the surface of the stents and that NO release favors their endothelization. Thus, mP(DC-co-DMSNO) may emerge as a new platform for the fabrication of advanced BVS. (AU) | |
| Processo FAPESP: | 18/02520-5 - Stents bioabsorvíveis de poliésteres polinitrosados doadores de óxido nítrico |
| Beneficiário: | Matheus Fernandes de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 16/02414-5 - Biomateriais absorvíveis e tópicos para a liberação localizada de óxido nítrico |
| Beneficiário: | Marcelo Ganzarolli de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/14142-5 - Hidrogéis híbridos para liberação localizada e prolongada de óxido nítrico |
| Beneficiário: | Laura Caetano Escobar da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/00491-0 - Hidrogéis termosensíveis de Pluronic F127 funcionalizados com grupos terminais liberadores de óxido nítrico |
| Beneficiário: | Marcos Vinicius Lorevice |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |