The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil

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Fonseca, Luciana M. ; Haddad, Glenda G. ; Mattar, Guilherme P. ; de Oliveira, Melaine C. ; Simon, Sharon S. ; Guilhoto, Laura M. ; Busatto, Geraldo F. ; Zaman, Shahid ; Holland, Anthony J. ; Hoexter, Marcelo Q. ; Bottino, Cassio M.

• Tipo de documento: Artigo Científico
• Fonte: Revista Brasileira de Psiquiatria; v. 41, n. 3, p. 9-pg., 2019-05-01.

Resumo

Objective: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliability of the Brazilian version of the Cambridge Examination for Mental Disorders of Older People with Down's syndrome and Others with Intellectual Disabilities (CAMDEX-DS) for individuals with DS. Methods: Two psychiatrists, working independently, evaluated 92 adults with DS >= 30 years of age. The concurrent validity of the CAMDEX-DS was analyzed in relation to the gold standard of established international criteria. In a subgroup of 20 subjects, the concurrent validity of the CAM DEX-DS was analyzed in relation to an independent objective assessment of cognitive decline over three years. We analyzed the inter-rater reliability of cognitive assessment. Results: The diagnostic accuracy of the CAMDEX-DS compared to the gold standard was 96.7%. CAMDEX-DS-based diagnosis was considered consistent with cognitive decline. The probability of a participant with dementia having cognitive decline was 83%. Inter-rater reliability for the participant assessment was good, with a kappa of > 0.8 for 93% of the CAMDEX-DS items. Conclusion: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research. (AU)

• Processo FAPESP: 16/22123-5 - Proposta de estágio de pesquisa em demência, Síndrome de Down e neuroimagem no Departamento de Psiquiatria da Universidade de Cambridge
• Beneficiário: Luciana Mascarenhas Fonseca
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 13/11571-9 - Investigação sobre fatores de risco para declínio cognitivo e demência em adultos com Síndrome de Down e validação do CAMDEX-DS
• Beneficiário: Luciana Mascarenhas Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto