Respiratory and peripheral muscle strength influence recovery of exercise capacity after severe exacerbation of COPD? An observational prospective cohort study

Autor(es)

Heubel, Alessandro D. ; Kabbach, Erika Z. ; Leonardi, Naiara T. ; Schafauser, Nathany S. ; Kawakamia, Debora M. O. ; Sentanin, Anna Claudia ; Di Lorenzoa, Valeria A. Pires ; Silva, Audrey Borghi ; Hurst, John R. ; Mendes, Renata G.

• Tipo de documento: Artigo Científico
• Fonte: HEART & LUNG; v. 58, p. 7-pg., 2023-03-01.

Resumo

Background: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have decreased exercise tolerance, which may persist for months. In this context, little is known about the associations between muscle strength and recovery of exercise capacity. Objective: To assess whether respiratory and peripheral muscle strength influence recovery of exercise capacity in patients hospitalized due to AECOPD. Methods: Twenty-seven AECOPD patients (aged 69 +/- 7 years, 56% male) were included. The following assessments were performed within 24 to 72 h of hospital admission: (i) respiratory muscle strength, measured by maximal inspiratory and expiratory pressures (MIP and MEP); (ii) peripheral muscle strength, assessed by handgrip and quadriceps muscle strength; and (iii) exercise capacity, measured by 6-min walking distance (6MWD). The 6MWD was reassessed 30 days later to determine the recovery of exercise capacity. Results: After 30 days, while 63% of the patients showed clinically important improvement in the 6MWD (recovery >= 30 m), 37% showed no change (recovery < 30 m). During hospital stay, the non-recovered group had lower quadriceps muscle strength compared to the recovered group (15 +/- 5 vs. 22 +/- 6 kgf; P = 0.006), with no significant difference for MIP, MEP and handgrip strength. Only quadriceps muscle strength was associated with recovery of exercise capacity (r = 0.56; P = 0.003). Conclusion: AECOPD patients with quadriceps muscle weakness during hospitalization have poor recovery of exercise capacity after 30 days. This finding suggests the importance of early rehabilitation to improve quad-riceps strength and accelerate functional recovery after AECOPD. (c) 2022 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 15/26501-1 - Estudo dos fatores limitantes ao exercício físico e efeitos dos recursos adjuntos à reabilitação nas doenças cardiorrespiratórias crônicas: uma abordagem multicêntrica
• Beneficiário: Audrey Borghi Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/12763-4 - A exacerbação da DPOC isolada e na coexistência da IC e o suporte ventilatório não invasivo: investigação do impacto sobre a função endotelial e autonômica cardíaca e análise da relação dos desfechos cardiovasculares com aspectos clincos e funcionais
• Beneficiário: Renata Gonçalves Mendes
• Modalidade de apoio: Auxílio à Pesquisa - Regular