| Texto completo | |
| Autor(es): |
Fiorin, Luiz Guilherme
;
Matheus, Henrique Rinaldi
;
Ervolino, Edilson
;
Canciani, Elena
;
Pellegrini, Gaia
;
Dellavia, Claudia
;
Maiorana, Carlo
;
de Almeida, Juliano Milanezi
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PERIODONTAL RESEARCH; v. 57, n. 4, p. 11-pg., 2022-08-01. |
| Resumo | |
Background The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm(2), and no differences regarding BMP-2/4 positive cells/mm(2) than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats. (AU) | |
| Processo FAPESP: | 19/24825-5 - Influência do tamoxifeno associado a quimioterápicos nos tecidos periimplantares |
| Beneficiário: | Luiz Guilherme Fiorin |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/11427-8 - Influência de drogas quimioterápicas na evolução da periodontite experimental em ratos |
| Beneficiário: | Juliano Milanezi de Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/11688-4 - Influência do tamoxifeno na remodelação óssea periimplantar |
| Beneficiário: | Luiz Guilherme Fiorin |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |