Autor(es)

Canales, Giancarlo De la Torre ; Poluha, Rodrigo Lorenzi ; Alvarez Pinzon, Natalia ; Da Silva, Bruno Rodrigues ; Almeida, Andre Mariz ; Ernberg, Malin ; Manso, Ana Cristina ; Bonjardim, Leonardo Rigoldi ; Rizzatti-Barbosa, Celia Marisa

• Tipo de documento: Artigo Científico
• Fonte: TOXINS; v. 14, n. 7, p. 9-pg., 2022-07-01.

Resumo

This study assessed the effects of botulinum toxin type A (BoNT-A) in mandibular range of motion and muscle tenderness to palpation in persistent myofascial pain (MFP) patients (ReBEC RBR-2d4vvv). Eighty consecutive female subjects with persistent MFP, were randomly divided into four groups (n = 20): three BoNT-A groups with different doses and a saline solution group (placebo control group). Treatments were injected bilaterally in the masseter and anterior temporalis muscle in a single session. Clinical measurements of mandibular movements included: pain-free opening, maximum unassisted and assisted opening, and right and left lateral excursions. Palpation tests were performed bilaterally in the masseter and temporalis muscle. Follow-up occurred 28 and 180 days after treatment. For the statistical analysis the Mann-Whitney U-test with Bonferroni correction was used for groups comparisons. Regardless of dose, all parameters of mandibular range of motion significantly improved after 180 days in all BoNT-A groups, compared with the control group. Palpation pain over the masseter and temporalis muscles were significantly reduced in all BoNT-A groups regardless of dose, compared with the control group, after 28 and 180 days of treatment. Independent of doses, BoNT-A improved mandibular range of motion and muscle tenderness to palpation in persistent MFP patients. (AU)

• Processo FAPESP: 14/15863-7 - Comparação do grau de eficiência do tratamento convencional e do tratamento com TXB-A em portadores de disfunção temporomandibular miogênica e dor crônica
• Beneficiário: Celia Marisa Rizzatti Barbosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular