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Antibacterial, Antiparasitic, and Cytotoxic Activities of Chemical Characterized Essential Oil of Chrysopogon zizanioides Roots

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Autor(es):
Oliveira, Thais A. S. ; Vieira, Tatiana M. ; Esperandim, Viviane R. ; Martins, Carlos H. G. ; Magalhaes, Lizandra G. ; Miranda, Mayker L. D. ; Crotti, Antonio E. M.
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: PHARMACEUTICALS; v. 15, n. 8, p. 11-pg., 2022-08-01.
Resumo

This study aimed to investigate the chemical composition as well as the antibacterial, antiparasitic, and cytotoxic potentialities of the Brazilian Chrysopogon zizanioides root essential oil (CZ-EO) In addition, CZ-EO cytotoxicity to LLCMK2 adherent epithelial cells was assessed. The major compounds identified in CZ-EO were khusimol (30.0 +/- 0.3%), beta-eudesmol (10.8 +/- 0.3%), alpha-muurolene (6.0 +/- 0.1%), and patchouli alcohol (5.6 +/- 0.2%). CZ-EO displayed optimal antibacterial activity against Prevotella nigrescens, Fusobacterium nucleatum, Prevotella melaninogenica, and Aggregatibacter actinomycetemcomitans, with Minimum Inhibitory Concentration (MIC) values between 22 and 62.5 mu g/mL and Minimum Bactericidal Concentration (MBC) values between 22 and 400 mu g/mL. CZ-EO was highly active against the L. amazonensis promastigote and amastigote forms (IC50 = 7.20 and 16.21 mu g/mL, respectively) and the T. cruzi trypomastigote form (IC50 = 11.2 mu g/mL). Moreover, CZ-EO showed moderate cytotoxicity to LLCMK2 cells, with CC50 = 565.4 mu g/mL. These results revealed an interesting in vitro selectivity of CZ-EO toward the L. amazonensis promastigote and amastigote forms (Selectivity Index, SI = 78.5 and 34.8, respectively) and the T. cruzi trypomastigote form (SI = 50.5) compared to LLCMK2 cells. These results showed the promising potential of CZ-EO for developing new antimicrobial, antileishmanial, and antitrypanosomal drugs. (AU)

Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
Beneficiário:Antônio Eduardo Miller Crotti
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores