Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review

Autor(es)

Fiod Riccio, Bruno Vincenzo ; Polli Silvestre, Amanda Leticia ; Meneguin, Andreia Bagliotti ; Ribeiro, Tais de Cassia ; Klosowski, Ana Beatriz ; Colerato Ferrari, Priscileila ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: AAPS PHARMSCITECH; v. 23, n. 7, p. 23-pg., 2022-09-28.

Resumo

Polymeric films are drug delivery systems that maintain contact with the delivery tissue and sustain a controlled release of therapeutic molecules. These systems allow a longer time of drug contact with the target site in the case of topical treatments and allow the controlled administration of drugs. They can be manufactured by various methods such as solvent casting, hot melt extrusion, electrospinning, and 3D bioprinting. Furthermore, they can employ various polymers, for example PVP, PVA, cellulose derivatives, chitosan, gelling gum, pectin, and alginate. Its versatility is also applicable to different routes of administration, as it can be administered to the skin, oral mucosa, vaginal canal, and eyeballs. All these factors allow numerous combinations to obtain a better treatment. This review focuses on exploring some possible ways to develop them and some particularities and advantages/disadvantages in each case. It also aims to show the versatility of these systems and the advantages and disadvantages in each case, as they bring the opportunity to develop different medicines to facilitate therapies for the most diverse purposes . (AU)

• Processo FAPESP: 19/00164-0 - Dispersões sólidas de trans-resveratrol Incorporadas em membranas de polivinilpirrolidona para aplicação cutânea: desenvolvimento, caracterização e avaliação biológica in vitro e in vivo
• Beneficiário: Bruno Vincenzo Fiod Riccio
• Modalidade de apoio: Bolsas no Brasil - Mestrado