| Texto completo | |
| Autor(es): |
Domingues Silva, Gabriela Vivili
;
Dolens, Eder da Silva
;
Ribeiro Paranaiba, Livia Maris
;
Carrinho Ayroza, Ana Lucia
;
Gurgel Rocha, Clarissa Araujo
;
Almangush, Alhadi
;
Salo, Tuula
;
Brennan, Peter A.
;
Coletta, Ricardo D.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. N/A, p. 8-pg., 2022-10-03. |
| Resumo | |
Background While the relevance of the World Health Organization histopathological grading system as a prognostic tool for oral squamous cell carcinoma has received many critics, other histopathological features such as tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding are displaying promising results. Here, we evaluated the prognostic impact of the incorporation of tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding into World Health Organization histopathological grading for patients with oral squamous cell carcinoma. Methods A total of 95 patients with early-stage oral squamous cell carcinoma were enrolled in the study, and World Health Organization tumor grading, tumor-stroma ratio, tumor-infiltrating lymphocytes, and tumor budding were evaluated in surgical slides stained with hematoxylin and eosin. Survival analyses for cancer-specific survival and disease-free survival were performed using Cox regression models, and receiver operating characteristic curves were applied for assessment of the performance of the combinations. Results Tumor-stroma ratio (stroma-rich) was significantly and independently associated with both shortened cancer-specific survival and poor disease-free survival, individually and in combination with World Health Organization histopathological grading. The combination of tumor-stroma ratio with World Health Organization grading did not improve the discriminatory ability compared to tumor-stroma ratio alone. Although low tumor-infiltrating lymphocytes were associated with shortened cancer-specific survival, the association did not withstand multivariate analysis. However, in combination with World Health Organization grading, low tumor-infiltrating lymphocytes were independently associated with poor cancer-specific survival. The combination of tumor-infiltrating lymphocytes and World Health Organization histopathological grading displayed a better discrimination of poor cancer-specific survival than tumor-infiltrating lymphocytes alone, but not at a significant level. Conclusion Our findings support tumor-stroma ratio as a potential prognostic marker for patients with oral squamous cell carcinoma, and the incorporation of tumor-infiltrating lymphocytes into the World Health Organization grading system improves the prognostic ability of the tumor grading alone. (AU) | |
| Processo FAPESP: | 21/13595-9 - Impacto prognóstico da associação do sistema de classificação histopatológica com budding tumoral, proporção tumor-estroma e linfócitos infiltrantes do tumor em pacientes com carcinoma de células escamosas oral em estágio clínico inicial. |
| Beneficiário: | Gabriela Vivili Domingues Silva |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 18/16077-6 - Análise do Valor Prognóstico e Papel Biológico de Proteínas Superexpressas no Carcinoma de Células Escamosas Oral Identificadas por Meio de Proteômica Baseada em Espectrometria de Massas |
| Beneficiário: | Ricardo Della Coletta |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |