Polypropylene Modified with Ag-Based Semiconductors as a Potential Material against SARS-CoV-2 and Other Pathogens

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Assis, Marcelo ; Ribeiro, Lara K. ; Goncalves, Mariana O. ; Staffa, Lucas H. ; Paiva, Robert S. ; Lima, Lais R. ; Coelho, Dyovani ; Almeida, Lauana F. ; Moraes, Leonardo N. ; Rosa, Ieda L. V. ; Mascaro, Lucia H. ; Grotto, Rejane M. T. ; Sousa, Cristina P. ; Andres, Juan ; Longo, Elson ; Cruz, Sandra A.

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED POLYMER MATERIALS; v. 4, n. 10, p. 13-pg., 2022-09-16.

Resumo

The worldwide outbreak of the coronavirus pandemic (COVID-19) and other emerging infections are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. It is noteworthy that Ag-based semiconductors can help orchestrate several strategies to fight this serious societal issue. In this work, we present the synthesis of alpha-Ag2WO4, beta-Ag2MoO4, and Ag2CrO4 and their immobilization in polypropylene in the amounts of 0.5, 1.0, and 3.0 wt %, respectively. The antimicrobial activity of the composites was investigated against the Gram-negative bacterium Escherichia coli, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans. The best antimicrobial efficiency was achieved by the composite with alpha-Ag2WO4, which completely eliminated the microorganisms in up to 4 h of exposure. The composites were also tested for the inhibition of SARS-CoV-2 virus, showing antiviral efficiency higher than 98% in just 10 min. Additionally, we evaluated the stability of the antimicrobial activity, resulting in constant inhibition, even after material aging. The antimicrobial activity of the compounds was attributed to the production of reactive oxygen species by the semiconductors, which can induce high local oxidative stress, causing the death of these microorganisms. (AU)

• Processo FAPESP: 16/13423-5 - Compostos produzidos por microrganismos endofíticos isolados de plantas do cerrado: bioatividade, associação com a-Ag2WO4 e aplicações biotecnológicas
• Beneficiário: Cristina Paiva de Sousa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 17/11986-5 - Geração e Armazenamento de Novas Energias: trazendo desenvolvimento tecnológico para o país
• Beneficiário: Ana Flávia Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia