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Heterocyclic agrochemical hosted by cyclodextrin and hybrid cyclodextrin-silica materials: Characterization, release behavior, and mobility in soil

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Autor(es):
Carvalho, Lucas Braganca ; Venceslau, Adneia de Fatima Abreu ; Breisch, Daniela Luz Ambrosio ; Fraceto, Leonardo Fernandes ; Jaime, Carlos ; Pinto, Luciana Matos Alves
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 656, p. 11-pg., 2023-01-05.
Resumo

Atrazine (ATZ) formulations are used to control a broad spectrum of weeds. The combination of ATZ with macromolecular systems, such as cyclodextrins (CDs), can improve its usefulness and herbicide efficacy related to the controlled release of the active ingredient. In this study, inclusion complexes of ATZ in CD and hybrid cyclodextrin-silica materials (CDSI) were prepared and characterized. Infrared spectral analysis of the inclusion compounds, concomitant with the suppression of the endothermic differential scanning calorimetry (DSC) peaks related to the fusion temperature of ATZ, confirmed the inclusion of ATZ in the functionalized and non-functionalized oligosaccharides. The linear increase in ATZ solubilization with the increasing addition of CD indicated that the inclusion stoichiometry was 1:1 in all studied systems. The increase in solubilization of the herbicide was approximately 1.3 times for alpha-CD and gamma-CD, which had association constants of 20.3 and 13.4 L mol-1, respectively. The increase in solubility for alpha-CDSI and gamma-CDSI was 3.3 and 2.7-fold, and the association constants were 161.1 and 111.1 L mol-1, respectively. Molecular mechanics (MM) calculations were performed using the force fields MM3* and AMBER*, and the results indicated that the most stable conformations resulted from the penetration of ATZ through the narrower cavity of the CDs. The MD calculations indicated three possible orientations for ATZ in the alpha-CD cavity, while for gamma-CD the amplitude of the standard deviation of the energy values made it impossible to select a more favorable orientation. The ATZ release profile was affected by complexation. Over 22 h, more than 50% of noncomplexed ATZ was released, while for the complexes, less than 20% was released. The complexation, as well as the commercial formulation, provided variations in the devel-opment of Brassica juncea seedlings for the layers with higher concentrations of ATZ, thus agreeing with soil layer mobility studies indicated that complexation did not increase the leaching capacity of ATZ, which was mainly distributed in the upper soil layers, where it may be more available for herbicide control functions. (AU)

Processo FAPESP: 17/21004-5 - Agricultura, micro/nanotecnologia e ambiente: da avaliação dos mecanismos de ação a estudos de transporte e toxicidade
Beneficiário:Leonardo Fernandes Fraceto
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/23608-8 - Desenvolvimento de nanopesticidas marcados com sondas fluorescentes para estudos de mecanismo de ação e toxicidade
Beneficiário:Lucas Bragança de Carvalho
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado