Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes

Autor(es)

de Souza, Wanderson C. C. ; Lima, Rafaely N. N. ; de Jesus, Iva S. S. ; Correia, Jose Tiago M. ; Paixao, Marcio W.

• Tipo de documento: Artigo Científico
• Fonte: SYNTHESIS-STUTTGART; v. N/A, p. 10-pg., 2022-12-20.

Resumo

A deaminative alkyl radical cascade cyclization of 1,7dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection of cyclopentaquinolinones. (AU)

• Processo FAPESP: 21/06099-5 - Desenvolvimento de novas metodologias fotoquímicas para síntese de pequenas moléculas e modificações de biomoléculas
• Beneficiário: Márcio Weber Paixão
• Modalidade de apoio: Auxílio à Pesquisa - Regular