| Texto completo | |
| Autor(es): |
Vila, Marta M. D. C.
;
Boscariol, Rodrigo
;
Balcao, Victor M.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Química Nova; v. N/A, p. 7-pg., 2023-01-17. |
| Resumo | |
Curcumin, a phytochemical, exhibits several biological properties and has been studied for the treatment of psoriasis. To facilitate its transdermal permeation, permeation enhancers such as choline and geranic acid ionic liquid (CAGE-IL) have been studied. From this perspective, the research effort entertained herein aimed at developing and evaluating the stability of an emulsion prepared with curcumin (phytochemical from Curcuma longa L.) and locust bean gum (extracted from the seeds of the carob tree, Ceratonia siliqua), with CAGE-IL as a facilitator of transdermal permeation. Stability studies were carried out for six months, with analyses being performed at time intervals of 0 (24 h), 30, 60, 90, and 180 days. The samples were kept at 40 +/- 2 degrees C, with 75 +/- 5% relative humidity (RH). The parameters analyzed were morphological characteristics, pH (5.8-6.0), and spreadability. The samples were shown to be stable during the timeframe studied, maintaining adequate physicochemical characteristics and meeting quality specifications for cutaneous applications. CAGE-IL, in addition to facilitating permeation of the active substance, also favored the formation of a stable emulsion encompassing nanosized particles (134.3 +/- 2.6 nm) in a simple fashion and with only a few components. (AU) | |
| Processo FAPESP: | 16/12234-4 - TransAppIL - Permeação cutânea de entidades proteicas estabilizadas estruturalmente e funcionalmente, carreadas por líquidos iônicos. |
| Beneficiário: | Marta Maria Duarte Carvalho Vila |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/08884-3 - PneumoPhageColor - desenvolvimento de um kit de biodetecção colorimétrica de Pseudomonas aeruginosa com base em partículas fágicas |
| Beneficiário: | Vitor Manuel Cardoso Figueiredo Balcão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/05522-9 - PsaPhageKill - isolamento, caracterização e uso de bacteriófagos líticos contra Pseudomonas syringae pv. actinidiae para combater o cancro do kiwi: uma alternativa eficiente e amiga do ambiente |
| Beneficiário: | Vitor Manuel Cardoso Figueiredo Balcão |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |