| Texto completo | |
| Autor(es): |
Ministro, Gabriela
;
Castano, Javier B.
;
Barboza, Catarina A.
;
Moura, Eliezer G.
;
Ferreira-Melo, Silvia E.
;
Mostarda, Cristiano T.
;
Fattori, Andre
;
Moreno-Junior, Heitor
;
Rodrigues, Bruno
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Respiratory Physiology & Neurobiology; v. 297, p. 8-pg., 2022-03-01. |
| Resumo | |
Here, we assessed the impact of one session of transcranial direct current stimulation (tDCS) or SHAM (20 min, each) on ventilatory responses to cardiopulmonary exercise test, central and peripheral blood pressure (BP), and autonomic modulation in resistant hypertensive (RHT) patients. RHT subjects (n = 13) were randomly submitted to SHAM and tDCS crossing sessions (1 week of "washout"). Patients and a technician who set the tDCS/Sham room up were both blind. After brain stimulation, patients were submitted to a cardiopulmonary exercise test to evaluate ventilatory and cardiovascular response to exercise. Hemodynamic (Finometer (R), Beatscope), and autonomic variables were measured at baseline (before tDCS/Sham) and after incremental exercise. Our study shows that tDCS condition improved heart rate recovery, VO2 peak, and vagal modulation (after cardiopulmonary exercise test); attenuated the ventilatory variability response, central and peripheral blood pressure well as sympathetic modulation (after cardiopulmonary exercise test) in comparison with SHAM. These data suggest that acute tDCS sessions prevented oscillatory ventilation behavior during the cardiopulmonary exercise test and mitigated the increase of systolic blood pressure in RHT patients. After the exercise test, tDCS promotes better vagal reentry and improved autonomic modulation, possibly reducing central blood pressure and aortic augmentation index compared to SHAM. Brazilian Registry of Clinical Trials (ReBEC): https://ensaiosclinicos.gov.br/rg/RBR-8n7c9p. (AU) | |
| Processo FAPESP: | 16/18104-5 - Efeito simpatolítico da estimulação transcraniana por corrente direta (tDCS) sobre a pressão arterial em hipertensos resistentes - Uma nova perspectiva terapêutica |
| Beneficiário: | Heitor Moreno Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/24726-1 - Efeitos da estimulação transcraniana por corrente direta (tDCS) associada ao exercício físico aeróbio em pacientes hipertensos resistentes: parâmetros ventilatórios, hemodinâmicos, autonômicos e imunológicos |
| Beneficiário: | Catarina de Andrade Barboza |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |