Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review

Autor(es)

Martins Humberto, Janaina Silva ; Pavanin, Jefferson Veronezi ; Alves da Rocha, Maria Jose ; Fragoso Motta, Ana Carolina

• Tipo de documento: Artigo Científico
• Fonte: BRAZILIAN ORAL RESEARCH; v. 32, p. 11-pg., 2018-01-01.

Resumo

The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-Upsilon, and TNF-alpha, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP. (AU)

• Processo FAPESP: 15/22183-5 - Aspectos neuroimunoendócrinos em pacientes com diagnóstico de Líquen Plano Oral
• Beneficiário: Karla Karine Duarte Maia
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/11883-3 - Perfil clínico, histopatológico e imunopatológico de pacientes com diagnóstico de líquen plano oral
• Beneficiário: Ana Carolina Fragoso Motta
• Modalidade de apoio: Auxílio à Pesquisa - Regular