Single nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in children

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Scariot, Rafaela ; Brunet, Leonardo ; Olsson, Bernardo ; Palinkas, Marcelo ; Hallak Regalo, Simone Cecilio ; Barbosa Rebellato, Nelson Luis ; Brancher, Joao Armando ; Torres, Carolina Paes ; Diaz-Serrano, Kranya Victoria ; Kuchler, Erika Calvano ; Zielak, Joao Cesar

• Tipo de documento: Artigo Científico
• Fonte: CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE; v. 40, n. 2, p. 8-pg., 2019-12-25.

Resumo

Objective: To evaluate the association of bruxism phenotypes with single nucleotide polymorphisms in FKBP5, DRD2, ANKK1, and COMT. Methods: Clinical oral examination was performed to diagnose bruxism phenotypes in 150 children. DNA was collected from saliva. Logistic univariate regression, Chi-square, and Fisher's exact tests were performed (p < 0.05). Results: Bruxism was associated with DRD2 (p = 0.02). Tooth grinding while awake was associated with ANKK1 (p < 0.001), and tooth grinding while asleep was associated with DRD2 in the additive (p = 0.030) and dominant (p = 0.008) model. Tooth clenching while awake was associated with ANKK1 in the additive (p = 0.005) and dominant (p = 0.008) models, whereas tooth clenching while asleep was associated with ANKK1 (p < 0.001) and with COMT in the additive (p = 0.001) and dominant (p = 0.003) models. Discussion: Polymorphisms in DRD2, ANKK1, and COMT are associated with bruxism phenotypes. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores