Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas

Autor(es)

Dourado, Mauricio Rocha ; Machado, Renato Assis ; Paranaiba, Livia Maris Ribeiro ; Gonzalez-Arriagada, Wilfredo Alejandro ; da Silva, Sabrina Daniela ; Sawazaki-Calone, Iris ; Graner, Edgard ; Salo, Tuula ; Coletta, Ricardo D.

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 28, n. 4, p. 9-pg., 2021-03-05.

Resumo

Background Trophoblast cell surface antigen 2 (TROP2) has unclear clinical role in oral squamous cell carcinomas (OSCC). Here, we investigated the association of TROP2 immunoexpression with clinicopathological parameters and survival of OSCC patients. Subjects and Methods Cancer-specific survival (CSS) and disease-free survival (DFS) were assessed in a cohort composed of 266 OSCC. An independent cohort with 88 OSCC samples matched with the normal oral tissue, as well as 17 metastatic lymph nodes, was used for validation. Results Multivariate analysis showed TROP2 as an independent marker of favorable prognosis for both CSS (HR: 0.60, 95% CI: 0.40-0.90, p = .01) and DFS (HR: 0.57, 95% CI: 0.36-0.89, p = .01). Furthermore, TROP2 protein expression was significantly higher in morphologically normal tissues compared to primary tumors (p < .0001) and lymph node metastases (p = .001), and it was significantly associated with CSS (HR: 0.26, 95% CI: 0.09-0.74, p = .008) in the validation cohort. A pooled mRNA analysis performed on the Oncomine (TM) database confirmed the underexpression in OSCC compared with normal tissues (p = .014). Conclusions In summary, our results point to a favorable prognostic significance of TROP2 overexpression in a large cohort of oral cancer patients, suggesting it as an attractive clinical marker. (AU)

• Processo FAPESP: 17/26764-8 - Análise do valor prognóstico e papel biológico de proteínas superexpressas no carcinoma espinocelular oral identificadas por meio de proteômica baseada em espectrometria de massas
• Beneficiário: Mauricio da Rocha Dourado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/16077-6 - Análise do Valor Prognóstico e Papel Biológico de Proteínas Superexpressas no Carcinoma de Células Escamosas Oral Identificadas por Meio de Proteômica Baseada em Espectrometria de Massas
• Beneficiário: Ricardo Della Coletta
• Modalidade de apoio: Auxílio à Pesquisa - Regular