Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis

Autor(es)

Kukulka, Elisa Camargo ; de Souza, Joyce Rodrigues ; Ribeiro de Araujo, Juliani Carolini ; Reis de Vasconcellos, Luana Marotta ; Bastos Campos, Tiago Moreira ; Thim, Gilmar Patricinio ; Souto Borges, Alexandre Luiz

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 111, n. 1, p. 11-pg., 2022-07-19.

Resumo

The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol-gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li). In PCL/acetone solutions were added 7% pure bioglass, bioglass doped with Mg(NO3)(2) and Li2CO3 and were subjected to electrospinning process. The fibers obtained were characterized morphologically, chemically and biologically. The results showed the presence of fine fibers at the nanometric scale and with diameters ranging from 0.67 to 1.92 mu m among groups. Groups containing bioglass showed particles both inside and on the surface of the fibers. The components of the polymer, bioglass and therapeutic ions were present in the fibers produced. The produced fibers showed cell viability and induced the formation of mineralization nodules. It was observed the applicability of that methodology in making an improved biomaterial, which adds the osteoinductive properties of the bioglass to PCL and to those of therapeutic ions, applicable to guided bone regeneration. (AU)

• Processo FAPESP: 20/12874-9 - Infiltração gradada por vidro em um compósito experimental à base de whiskers de alumina e zircônia: desenvolvimento, caracterização microestrutural e das propriedades ópticas e mecânicas
• Beneficiário: Tiago Moreira Bastos Campos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/12507-6 - Desenvolvimento e caracterização de cimento de wollastonita para engenharia de tecido ósseo
• Beneficiário: Gilmar Patrocínio Thim
• Modalidade de apoio: Auxílio à Pesquisa - Regular