Pedunculated, papillary giant cell fibroma in a pediatric patient: An immunohistochemical and in situ hybridization study

Autor(es)

Silveira, Heitor Albergoni ; Silva-Sousa, Yara Teresinha Correa ; Reyes, Magdalena Raquel Torres ; Bernardini, Vanessa da Rocha ; Floriam, Luis Jose ; Leon, Jorge Esquiche

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC DENTAL JOURNAL; v. 33, n. 1, p. 6-pg., 2023-03-15.

Resumo

Giant cell fibroma (GCF), a benign fibrous proliferation, represents about 4.7% of all benign/ reactive fibrous growths in the oral cavity. GCF preferentially affects Caucasians, with a peak incidence in the third decade of life, and slight female predilection. Clinically, small gingival nodules (about 1.0 cm in diameter) are often observed. Herein, we report a 5-year-old girl who was referred for evaluation of a pedunculated nodule on the gingiva, resem-bling a human papillomavirus (HPV)-associated papillary lesion clinically and microscop-ically. HPV was not detected by immunohistochemical and in situ hybridization analysis in the excised surgical specimen. Thus, the lesion was diagnosed as GCF. Papillary surface projections are rarely described in GCF, but it should be included in its clinicopathological spectrum, especially in pediatric patients.(c) 2023 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/12734-2 - Caracterização imunoistoquímica comparativa de subgrupos de células dendríticas e oncogênese viral no carcinoma espinocelular oral e orofaríngeo
• Beneficiário: Heitor Albergoni da Silveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 22/12760-9 - Correlação clinicopatológica do sistema imune, diferenciação celular, angiogênese, metabolismo lipídico e HPV transcricionalmente ativo em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular