| Texto completo | |
| Autor(es): |
Bouchmella, Karim
;
Lion, Quentin
;
Gervais, Christel
;
Cardoso, Mateus Borba
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS OMEGA; v. 8, n. 13, p. 11-pg., 2023-03-22. |
| Resumo | |
The mesoporous SBA-15 material was surface-functionalized with amino and carboxylic acid groups and used as a platform to investigate the interaction of these chemical groups with tetracycline, kanamycin, and ampicillin antibiotics. The interactions between the antibiotic and the functionalized surfaces were characterized using two-dimensional 1H-13C HETCOR CP MAS and FTIR spectroscopy and indicated that -COO-NH3+ bondings had been formed between chemical groups on the silica surface and drug molecules. The surface modification resulted in higher kanamycin and ampicillin loadings and a slow-release rate, and all synthesized systems showed antibacterial activity against susceptible Escherichia coli bacteria. Almost total death of bacteria was obtained using a few ppm of tetracycline-and kanamycin-loaded systems, whereas the ampicillin-loaded one showed lower bactericidal activity than free ampicillin. (AU) | |
| Processo FAPESP: | 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/22322-2 - Funcionalização de nanopartículas de sílica: aumentando a interação biológica |
| Beneficiário: | Mateus Borba Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |