Resolution of blood eosinophilia and limited mouth opening after short-term follow-up in a pediatric Langerhans cell histiocytosis case

Autor(es)

Reyes, Magdalena Raquel Torres ; Javaroni, Julia Biliato ; Nogueira, Gustavo Milhomens ; Zelaya, Florence Juana Maria Cuadra ; de Leon, Anyeli Soraya Alas ; Silveira, Heitor Albergoni ; Leon, Jorge Esquiche

• Tipo de documento: Artigo Científico
• Fonte: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY; v. 75, n. 3, p. 4-pg., 2023-05-02.

Resumo

IntroductionLangerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia that often affects children, presenting a broad clinical spectrum.MethodsHere, we report a 13-year-old male Salvadorian patient who was referred presenting a nodular swelling at the mandibular angle region, mildly symptomatic, few weeks ago, which relevantly was associated with limited mouth opening. Intraoral examination was unremarkable. Imaginological exams revealed an osteolytic lesion affecting the vestibular cortex at the right mandibular angle. The blood test results were normal, except for eosinophilia (21%; absolute eosinophil count 4 x 10(9)/L). After an incisional biopsy, microscopical and immunohistochemical analyses were consistent with LCH diagnosis, which corresponded to a single system-single site category. After a few weeks, the mandibular movements were re-established, and complete resolution of blood eosinophilia was observed.ConclusionLCH with blood eosinophilia is rarely reported. To our knowledge, 3 cases have been previously published. (AU)

• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/12760-9 - Correlação clinicopatológica do sistema imune, diferenciação celular, angiogênese, metabolismo lipídico e HPV transcricionalmente ativo em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular