| Texto completo | |
| Autor(es): Mostrar menos - |
Polachini, Giovana Mussi
;
de Castro, Tialfi Bergamin
;
Smarra, Luis Fabiano Soares
;
Henrique, Tiago
;
de Paula, Carlos Henrique Diniz
;
Severino, Patricia
;
Lopez, Rossana Veronica Mendoza
;
Carvalho, Andre Lopes
;
de Mattos Zeri, Ana Carolina
;
Silva, Ismael Dale Cotrim Guerreiro
;
Tajara, Eloiza H.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 13, n. 1, p. 21-pg., 2023-05-26. |
| Resumo | |
Metabolomics has proven to be an important omics approach to understand the molecular pathways underlying the tumour phenotype and to identify new clinically useful markers. The literature on cancer has illustrated the potential of this approach as a diagnostic and prognostic tool. The present study aimed to analyse the plasma metabolic profile of patients with oral squamous cell carcinoma (OSCC) and controls and to compare patients with metastatic and primary tumours at different stages and subsites using nuclear magnetic resonance and mass spectrometry. To our knowledge, this is the only report that compared patients at different stages and subsites and replicates collected in diverse institutions at different times using these methodologies. Our results showed a plasma metabolic OSCC profile suggestive of abnormal ketogenesis, lipogenesis and energy metabolism, which is already present in early phases but is more evident in advanced stages of the disease. Reduced levels of several metabolites were also associated with an unfavorable prognosis. The observed metabolomic alterations may contribute to inflammation, immune response inhibition and tumour growth, and may be explained by four nonexclusive views-differential synthesis, uptake, release, and degradation of metabolites. The interpretation that assimilates these views is the cross talk between neoplastic and normal cells in the tumour microenvironment or in more distant anatomical sites, connected by biofluids, signalling molecules and vesicles. Additional population samples to evaluate the details of these molecular processes may lead to the discovery of new biomarkers and novel strategies for OSCC prevention and treatment. (AU) | |
| Processo FAPESP: | 19/07293-0 - Perfil lipídico em Câncer de Cabeça e Pescoço |
| Beneficiário: | Tialfi Bergamin de Castro |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/07087-0 - Perfil lipídico em câncer de cabeça e pescoço |
| Beneficiário: | Tialfi Bergamin de Castro |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |
| Processo FAPESP: | 21/03647-1 - Marcadores de transição epitélio-mesenquimal e de homeostase metabólica associados a resistência ao quimioterápico cetuximabe e de sensibilidade colateral à piplartina em carcinoma de cabeça e pescoço |
| Beneficiário: | Carlos Henrique de Paula Diniz |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 11/23353-0 - Estudo de proteínas glicosiladas e metabólitos em carcinoma epidermóide de cavidade oral |
| Beneficiário: | Giovana Mussi Polachini |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço |
| Beneficiário: | Eloiza Helena Tajara da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |