| Texto completo | |
| Autor(es): |
Martins-Nascimento, Lilian S.
;
Brito, Adrianne M. M.
;
Bronzato, Julia D.
;
Oliveira, Martha T.
;
Costa, Silgia A.
;
Costa, Sirlene M.
;
Nascimento, Otaciro R.
;
Nantes, Iseli L.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY; v. 445, p. 10-pg., 2023-11-01. |
| Resumo | |
The COVID-19 pandemic increased the interest in the development of self-disinfecting materials. In this innovative study, cotton and polypropylene fabrics impregnated with the photochemically generated 10H-phenothiazine (PHT) radical cation (PHT & BULL;+) gained highly effective virucidal properties. The effectiveness of PHT & BULL;+ adsorption was demonstrated by advanced analytical techniques, including electron paramagnetic resonance (EPR), UV-visible, and FT-Raman spectroscopies that confirmed the presence of PHT & BULL;+ in the fabrics, even after washing and a re-exposure to light. Colorimetric test evidenced PHT & BULL;+ in the cotton fabric even after 2 months in the dark. Viral inactivation assays were performed with the fabrics treated with PHT. Results of qPCR showed that fabrics impregnated with PHT & BULL;+ were highly effective at reducing the viral genome compared to untreated fabrics. PHT & BULL;+ destroys the virus by an oxidative attack on the viral envelope, evidenced by the quenching of the EPR signal of fabrics exposed to a model of the virus envelope. Also, cryo-transmission electron microscopy captured stunning images of virus destruction caused by the oxidative attack of PHT & BULL;+ on the virus envelope. Overall, this study represents a significant advance in developing self-disinfecting materials and could have farreaching implications for the fight against viral infections. (AU) | |
| Processo FAPESP: | 17/02317-2 - Interfaces em materiais: propriedades eletrônicas, magnéticas, estruturais e de transporte |
| Beneficiário: | Adalberto Fazzio |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |