| Texto completo | |
| Autor(es): |
Imamura, Marta
;
Rebello-Sanchez, Ingrid
;
Parente, Joao
;
Marduy, Anna
;
Vasquez-Avila, Karen
;
Pacheco-Barrios, Kevin
;
Castelo-Branco, Luis
;
Simis, Marcel
;
Battistella, Linamara
;
Fregni, Felipe
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PM&R; v. N/A, p. 9-pg., 2023-10-05. |
| Resumo | |
Background: Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population.Objective: To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites.Design: Cross-sectional analysis of a prospective cohort.Setting: Primary care in public institution.Participants: 113 adults with KOA.Intervention: N/A.Main Outcome MeasuresMultivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed.Results: Both thenar region (adjusted-R-2: 0.29) and knee (adjusted-R-2: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: beta: -0.15, p = .002; knee: beta: -0.2, p < .001), and the 10-Meter Walking Test (thenar: beta: -0.05, p = .038; knee: beta: -0.08, p = .004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders.Conclusions: PPTs in KOA pain are associated with functional outcomes such as the 10-Meter Walking Test and activity-related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization. (AU) | |
| Processo FAPESP: | 17/12943-8 - O déficit da inibição como marcador de neuroplasticidade na reabilitação |
| Beneficiário: | Felipe Fregni |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa SPEC |