| Texto completo | |
| Autor(es): |
Floriano, Ricardo
;
Edalati, Kaveh
;
Pereira, Karina Danielle
;
Luchessi, Augusto Ducati
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 13, n. 1, p. 11-pg., 2023-01-10. |
| Resumo | |
The development of new biomaterials with outstanding mechanical properties and high biocompatibility has been a significant challenge in the last decades. Nanocrystalline metals have provided new opportunities in producing high-strength biomaterials, but the biocompatibility of these nanometals needs to be improved. In this study, we introduce metal-protein nanocomposites as high-strength biomaterials with superior biocompatibility. Small proportions of bovine serum albumin (2 and 5 vol%), an abundant protein in the mammalian body, are added to titanium, and two nanocomposites are synthesized using a severe plastic deformation process of high-pressure torsion. These new biomaterials show not only a high hardness similar to nanocrystalline pure titanium but also exhibit better biocompatibility (including cellular metabolic activity, cell cycle parameters and DNA fragmentation profile) compared to nano-titanium. These results introduce a pathway to design new biocompatible composites by employing compounds from the human body. (AU) | |
| Processo FAPESP: | 19/06951-3 - Rastreamento das ações moleculares do aminoácido hipusina |
| Beneficiário: | Augusto Ducati Luchessi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |