Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson's Disease

Autor(es)

Beretta, Victor Spiandor ; Vitorio, Rodrigo ; Nobrega-Sousa, Priscila ; Conceicao, Nubia Ribeiro ; Orcioli-Silva, Diego ; Pereira, Marcelo Pinto ; Bucken Gobbi, Lilian Teresa

• Tipo de documento: Artigo Científico
• Fonte: NEUROREHABILITATION AND NEURAL REPAIR; v. 34, n. 11, p. 11-pg., 2020-10-01.

Resumo

Background. Habituation of postural response to perturbations is impaired in people with Parkinson's disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective. To analyze the effect of different intensities of anodal tDCS on postural responses and prefrontal cortex (PFC) activity during the habituation to the external perturbation in patients with PD (n = 24). Methods. Anodal tDCS was applied over the primary motor cortex (M1) with 1 mA, 2 mA, and sham stimulation in 3 different sessions (similar to 2 weeks apart) during 20 minutes immediately before the postural assessment. External perturbation (7 trials) was applied by a support base posterior translation (20 cm/s and 5 cm). Primary outcome measures included lower limb electromyography and center of pressure parameters. Measures of PFC activity are reported as exploratory outcomes. Analyses of variance (Stimulation Condition x Trial) were performed. Results. Habituation of perturbation was evidenced independent of the stimulation conditions. Both active stimulation intensities had shorter recovery time and a trend for lower cortical activity in the stimulated hemisphere when compared to sham condition. Shorter onset latency of the medial gastrocnemius as well as lower cortical activity in the nonstimulated hemisphere were only observed after 2 mA concerning the sham condition. Conclusions tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA. However, tDCS seems to be inefficient in modifying the habituation of perturbation. (AU)

• Processo FAPESP: 18/07385-9 - Efeito da estimulação transcraniana por corrente contínua nos ajustes posturais sob perturbação externa em pacientes com Doença de Parkinson
• Beneficiário: Victor Spiandor Beretta
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/21499-1 - Atividade do córtex cerebral durante a locomoção humana: Influência do envelhecimento, da doença de Parkinson e do exercício físico agudo
• Beneficiário: Lilian Teresa Bucken Gobbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/22308-0 - Efeitos da Doença de Parkinson sobre medidas de eletroencefalografia durante o andar livre e a ultrapassagem de obstáculo
• Beneficiário: Rodrigo Vitório
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado