Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study

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de Luca, Ana Clara Falabello ; Marinho, Gabriella Bueno ; Franco, Juliana Bertoldi ; Tenorio, Jefferson da Rocha ; Andrade, Natalia Silva ; Batista, Alexandre Mendes ; Mamana, Ana Carolina ; Tozetto-Mendoza, Tania Regina ; Sayans, Mario Perez ; Braz-Silva, Paulo Henrique ; Ortega, Karem L.

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN MEDICINE; v. 10, p. 7-pg., 2023-06-22.

Resumo

Introduction: Torque teno virus ( TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics. Methods: Blood, saliva, clinical data from records and laboratory tests were collected from 72 cirrhotic patients. Plasma and saliva were submitted to realtime polymerase chain reaction for quantification of TTV viral load. Results: The majority of the patients presented decompensated cirrhosis (59.7%) and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients who were positive for TTV in plasma were also positive in saliva, with both fluids having a moderately positive correlation for the presence of TTV. There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied. Conclusion: TTV is more frequently found and in greater amount in the saliva than in the plasma of cirrhotic patients. There was no correlation between TTV viral load and clinical parameters. (AU)

• Processo FAPESP: 21/00708-0 - Avaliação de torque teno virus em sangue e saliva de pacientes cirróticos
• Beneficiário: Ana Clara Falabello de Luca
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/18938-6 - Avaliação da saúde bucal e do sangramento pós-exodôntico em pacientes no pré transplante de fígado.
• Beneficiário: Karem López Ortega
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/07490-0 - Biomarcadores salivares da COVID-19 e co-infecções virais respiratórias
• Beneficiário: Paulo Henrique Braz da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular