Acute Effects of Fluoxetine on Stress Responses and Feeding Motivation in Nile Tilapia

Autor(es)

Miranda, Julia P. G. A. ; Isaac, Ana Beatriz J. ; Silva, Rebeca B. ; Toledo, Leandro C. S. ; Barcellos, Leonardo J. G. ; Delicio, Helton Carlos ; Barreto, Rodrigo Egydio

• Tipo de documento: Artigo Científico
• Fonte: FISHES; v. 8, n. 7, p. 13-pg., 2023-07-01.

Resumo

The selective serotonin reuptake inhibitor fluoxetine is one of the most commonly administered psychotropic medications; however, it has been recognized as toxic to aquatic life. In this study, we showed that stress responses and feeding motivation in Nile tilapia were affected by acute exposure to fluoxetine. To reach that conclusion, we exposed Nile tilapia to 0, 1 or 10 & mu;g/L (environmentally/biologically relevant doses) of fluoxetine over a 24 h period and then exposed them to a handling stressor. We found that the 10 & mu;g/L dose enhanced cortisol response to stress but caused an earlier decrease in the ventilation boost induced by that stressor. An immediate ventilation boost after stressful stimuli indicates sympathetic activation. Thus, this suggests that fluoxetine decreased sympathetic nervous system activity but augmented hypothalamus-pituitary-interrenal axis activity in the fish. Both feeding latency and ingestion were similar among the tested conditions; however, a multiple logistic regression model revealed that in the presence of a stressor or fluoxetine, the Nile tilapia tended to ingest less food but there was a higher probability of this decrease to be associated with fluoxetine. We concluded that acute exposure to environmentally/biologically relevant fluoxetine concentrations over 24 h acted as a modifying factor for Nile tilapia stress physiology and tended to interfere with feeding motivation. An acute stress response is an emergency reaction that contributes to the recovery of homeostasis. In the presence of fluoxetine, modifications of acute stress responses and the tendency to reduce food intake, which restricts the ability to replace the energy spent on stress responses, could compromise the resumption of homeostasis and an animal's adjustment to different environmental contexts, such as those associated with aquaculture, in which anthropogenic stressors inevitably occur. (AU)

• Processo FAPESP: 21/05735-5 - Avaliação do óleo de cravo como sedativo para o camarão-da-Amazônia
• Beneficiário: Ana Beatriz Jodar Isaac
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 21/05772-8 - Efeitos de baixas concentrações do óleo de cravo durante o transporte na relação intruso-residente em camarões-da-Amazônia introduzidos em ambiente novo
• Beneficiário: Rebeca Beatriz Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 21/05768-0 - Avaliação comportamental de baixas concentrações de óleo de cravo para o transporte do camarão-da-Amazônia
• Beneficiário: Leandro Cesar Silva de Toledo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica