Insight toward inflammasome complex contribution to male infertility

Autor(es)

Minas, Aram ; Costa, Lucas Vasconcelos Soares ; Miyazaki, Mika Alexia ; Antoniassi, Mariana Pereira

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Reproductive Immunology; v. 90, n. 2, p. 14-pg., 2023-08-01.

Resumo

During the last decades, a wide range of factors involved in the physiopathology of male infertility disease have been discussed. The inflammation role in some of the main infertility-related diseases has been studied, such as varicocele, spinal cord injury and obesity. Inflammation is the main response of the immune system to infection or cell damage, leading to intense inflammatory cytokine release during the loss of homeostasis. One of the first steps toward pro-inflammatory cytokines release is the recognition of dangerous signals by the immune cells, including pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). These molecules can activate an important multiprotein complex, called inflammasome. Although these complexes have been studied during the last decades, their participation in male infertility has gained attention recently. Considering the inflammasome complex's high potential to be targeted for drug therapy, this review tries to shed light on current literature. Therefore, in the current review paper, we aimed to discuss the inflammasome complex activation, involvement in different male infertility conditions, and localization in the male reproductive tract. (AU)

• Processo FAPESP: 21/09149-3 - Cross-talk entre marcadores inflamatórios, citocinas e fatores de crescimento na varicocele; ênfase no envolvimento de macrófagos testiculares
• Beneficiário: Aram Minas
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/03753-6 - Influência da fragmentação de DNA espermático no desenvolvimento embrionário inicial
• Beneficiário: Mika Alexia Miyazaki
• Modalidade de apoio: Bolsas no Brasil - Mestrado