Autor(es)

De Moraes, T. F. ; Filho, J. C. C. ; Oishi, J. C. ; Almeida-Lopes, L. ; Parizotto, N. A. ; Rodrigues, G. J.

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 35, n. 5, p. 6-pg., 2019-10-29.

Resumo

The main purpose of this work was to construct an energy-dependent response curve of photobiomodulation on arterial pressure in hypertension animal model. To reach this objective, we have used a two-kidney one clip (2K-1C) rat model. Animals received acute laser light irradiation (660 nm) on abdominal region using different energy (0.6, 1.8, 3.6, 7.2, 13.8, 28.2, 55.8, and 111.6 J), the direct arterial pressure was measured by femoral cannulation, and systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and time of effect were obtained. Our results indicated that 660 nm laser light presents an energy-dependent hypotensive effect, and 28.2 J energy irradiation reached the maximum hypotensive effect, inducing a decreased SAP, DAP, and HR (decrease in SAP: - 19.23 +/- 1.82 mmHg, n = 11; DAP: - 9.57 +/- 2.23 mmHg, n = 11; HR: - 39.15 +/- 5.10 bpm, n = 11; and time of hypotensive effect: 3068.00 +/- 719.00 s, n = 11). The higher energy irradiation evaluated (111.6 J) did not induce a hypotensive effect and induced an increase in HR (21.69 +/- 7.89 bpm, n = 7). Taken together, our results indicate that red laser energy irradiation from 7.2 to 55.8 J is the effective therapeutic window to reduce SAP, DAP, MAP, and HR and induce a long-lasting hypotensive effect in rats, with effect loss at higher energy irradiation (111.6 J). (AU)

• Processo FAPESP: 18/10588-9 - Caracterização do efeito hipotensivo da fotobiomodulação em diferentes modelos animais de hipertensão arterial e estratégias farmacológicas para potencialização deste efeito
• Beneficiário: Gerson Jhonatan Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular