Autor(es)

de Oliveira, Tamires D. ; Plutin, Ana M. ; Luna-Dulcey, Liany ; Castellano, Eduardo E. ; Cominetti, Marcia R. ; Batista, Alzir A.

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 115, p. 11-pg., 2020-10-01.

Resumo

Five new complexes with general formula [Ru(L-n)(P-P)(bipy)]PF6, where L-n = N,N'-dimethyl-N-Acyl thiourea, and P-P: 1,2-bis(diphenylphosphino)ethane (dppe) or 1,4-bis(diphenylphosphino)butane (dppb)) were synthe- sized and characterized by elemental analysis, molar conductivity, cyclic voltammetry, IR, NMR CH, C-13{H-1} and P-31 {H-1}), and single crystal X-ray diffractometry. The cytotoxicity of compounds against lung and breast tumor cell lines was significant, where two complexes, [Ru(L-3)(bipy)(dppe)]PF6 (3) and [Ru(L-3)(bipy)(dppb)]PF6(6), were selected to evaluate changes in morphology, inhibition of migration and cell death in the MDA-MB-231 lineage. The complexes caused alterations in the cell morphology and were able to inhibit cell migration at the concentrations evaluated, induce the cell cycle arrested in the Sub-G1 phase, and induced cell death by apoptosis. All the complexes presented interaction with HSA, and the interaction studies with DNA suggested weak interactions, probably by the minor groove. (AU)

• Processo FAPESP: 18/05594-0 - Avaliação do mecanismo de ação do SSi6 na indução de autofagia e apoptose em células tumorais triplo negativas: estudos in vitro e in vivo
• Beneficiário: Liany Johanna Luna Dulcey
• Modalidade de apoio: Bolsas no Brasil - Doutorado