The Role of The Rostral Ventromedial Medulla in Stress Responses

Autor(es)

Pagliusi Jr, Marco ; Gomes, Felipe V.

• Tipo de documento: Artigo Científico
• Fonte: BRAIN SCIENCES; v. 13, n. 5, p. 10-pg., 2023-05-09.

Resumo

The rostral ventromedial medulla (RVM) is a brainstem structure critical for the descending pain modulation system involved in both pain facilitation and inhibition through its projection to the spinal cord. Since the RVM is well connected with pain- and stress-engaged brain structures, such as the anterior cingulate cortex, nucleus accumbens, and amygdala, its involvement in stress responses has become a matter of great interest. While chronic stress has been proposed as a trigger of pain chronification and related psychiatric comorbidities due to maladaptive stress responses, acute stress triggers analgesia and other adaptative responses. Here we reviewed and highlighted the critical role of the RVM in stress responses, mainly in acute stress-induced analgesia (SIA) and chronic stress-induced hyperalgesia (SIH), providing insights into pain chronification processes and comorbidity between chronic pain and psychiatric disorders. (AU)

• Processo FAPESP: 20/08363-9 - Estudo de vias aferentes para o bulbo rostral ventromedial na modulação do comportamento do tipo depressivo e da hiperalgesia induzidos pelo estresse social em camundongos
• Beneficiário: Marco Oreste Finocchio Pagliusi Junior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/17597-3 - O impacto do estresse sobre o sistema dopaminérgico é determinado pelo período crítico de plasticidade: implicações para a depressão e a esquizofrenia e o estudo de novos alvos farmacológicos
• Beneficiário: Felipe Villela Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores