Oximetry at admission as a predictor of tomographic and functional impairment after 3-6 months in hospitalized patients with COVID-19

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Villar, Pedro Maximink Esteves ; Mendes, Paulo Roberto Araujo ; Kiyota, Tatiana Alves ; Engleitner, Henrique Alcantara ; Tamesawa, Carolina Salem ; Morello, Mayara Magalhaes ; Basso, Nayara Nobre ; Arruda, Lucas Fileti ; Vian, Bruna Scharlack ; Ratti, Ligia dos Santos Roceto ; de Oliveira, Lais Bacchin ; Lima, Ana Lucia Cavallaro Barauna ; Ceccato, Hugo Dugolin ; Silva, Julian Furtado ; Villalba, Wander de Oliveira ; Conterno, Lucieni de Oliveira ; Resende, Mariangela Ribeiro ; Pereira, Monica Corso

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH; v. 51, n. 6, p. 13-pg., 2023-06-01.

Resumo

ObjectiveTo investigate characteristics that may be associated with radiologic and functional findings following discharge in patients with severe coronavirus disease 2019 (COVID-19). MethodsThis single-center, prospective, observational cohort study comprised patients aged >18 years who were hospitalized with COVID-19 pneumonia, between May and October 2020. After 3 to 6 months of discharge, patients were clinically evaluated and underwent spirometry, a 6-minute walk test (6MWT), and chest computed tomography (CT). Statistical analysis was performed using association and correlation tests. ResultsA total of 134 patients were included (25/114 [22%] were admitted with severe hypoxemia). On the follow-up chest CT, 29/92 (32%) had no abnormalities, regardless of the severity of the initial involvement, and the mean 6MWT distance was 447 m. Patients with desaturation on admission had an increased risk of remaining CT abnormalities: patients with SpO(2) between 88 and 92% had a 4.0-fold risk, and those with SpO(2) < 88% had a 6.2-fold risk. The group with SpO(2) < 88% also walked shorter distances than patients with SpO(2) between 88 and 92%. ConclusionInitial hypoxemia was found to be a good predictor of persistent radiological abnormalities in follow-up and was associated with low performance in 6MWT. (AU)

• Processo FAPESP: 20/10087-0 - Estudo prospectivo de uma coorte de pacientes egressos de internação por síndrome respiratória aguda grave e COVID-19: aspectos epidemiológicos, clínicos e funcionais
• Beneficiário: Mônica Corso Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular